The difference between 1-ply and 2-ply cocktail napkins comes down to thickness, absorbency, and durability: 1-Ply Napkins: Made with a single layer of paper, these napkins are thinner and less absorbent. They're often less expensive and work well for light use, such as a quick wipe or to accompany drinks at a casual gathering. 2-Ply Napkins: These napkins have two layers of paper, making them thicker, more absorbent, and more durable. They feel a bit softer and are generally better for handling spills or messy foods. They're popular for more upscale events where durability and a higher quality feel are important. For most cocktail settings, 2-ply napkins are preferred as they provide a more luxurious touch and are more practical for handling moisture from drinks.